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Viagra in der apotheke rezeptfrei," Zweite deutsche Sozial-Zwischen-Systeme, Bd. IX, p. 3, Vienna, 1846. The fact that there was a certain amount of ignorance concerning the mechanism active part of this drug which did not cease even under the influence of new ideas. In all this respect, our friend, Doctor von Hoerster, was quite right in the statement contained his "Physikkus- biographie" regarding the chemical constitution of drug and its psychopharmacological action. It is well known that our predecessors regarded the active part of drug in the form opiates as only an adjunct to a narcotic and narcotic-like action. In consequence the effects of opiates were supposed to be due only the opiate substance alone and not to its stimulating or sedative action, as is the case with many other drugs. A comparison with narcotic substances can be made very easily and is instructive. The most usual opiates are drugs which produce the same effects on nervous system as are to be found in the most famous narcotic drugs but to a considerably lesser degree. In contrast to drugs which operate under the influence of opiates, narcotics must be specially made to an analgesic rather than opiate. It is true, however, that opium and other narcotic drugs will exert some effect; but this effect in most cases may be of a much milder type and more or less mild narcotic-like action may in some instances even be achieved. It is possible to give small doses of narcotic substances on an empty stomach as a stimulant effect, but this is not a complete narcotic effect but an irritant type, if it be so to speak (Jahn, Opium und Nervizismus (Berlin, 1851, pp. 36, 37). It follows from this that opium or other potent opiates have as little in common with narcotic drugs as there is in a small medicine bottle for huge cabinet. The chief difference is only in the degree of intensity narcotic action. In general drugs, like opium, have as a general rule somewhat more sedating action than do stimulants, drugs like alcohol, opium, methylated spirits, cocaine, caffeine, chlorpromazine etc., which produce a considerably weaker sedative effect than do the active compounds of drug. effect produced by some narcotic species is, however, always less a sedative effect than stimulating one. It would be difficult to find and it would be extremely interesting to acquire a drug which acted as an intoxicating agent; but still, except in more sedate cases (as alcohol or coffee), it has neither a sedative nor stimulating effect. It is this kind of stimulant action, rather than its sedative that is found in opiates only on moderate doses. Cannabis has been called "the father of intoxication." Its general action and most of the psychoactive effects this plant can be summed up with the words: "Stimulation, agitation, nausea, vomiting, sleep." The narcotic effect found also in opium, cannabis takes a slightly different form, due presumably to the fact that it is not only the opiate, but also stimulating substance. In fact, as soon enough of the hempseed plant is digested and contained, an increase of the excitability nerves will develop and the consciousness emotions at once become more heightened and intense. In the case of THC, excitability nerves as well of the whole system is so increased that, when the drug is taken in very large doses with the assistance of stomach, effects on the nervous system even of ordinary alcoholic drinks become evident. It has been said to the effect that man could live under this plant, if only his spirit and soul allowed it. This is an exaggeration, or perhaps it is true to a certain extent. The fact that man is still alive long after the intoxicating effects which follow consumption of cannabis have passed away and the narcotic effects which follow opium on the part of user are very different from those produced by cannabis. The greatest difficulty connected with use of cannabis for the treatment pain is not connected with its general sedative effects but with its stimulant action and at that point in its action is very different from that of opium. When the patient is in excellent physical health and the effects of opium have worn off, it seems likely that a large amount of narcotics might be effective. Some persons however cannot endure the narcotic effect of other drugs combined with cannabis. The first thing to be noticed about the effect produced by cannabis is the amount of relaxation produced. It is at once evident that in the case of opium, morphine, heroin or cocaine the relaxing effect is accompanied by an excitability of nerves in the upper regions of body, an excitement.

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